iPhone 12 mini ظرفیت 128 گیگابایت

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1. 

   نمره 4 از 5

   Monroe – 28 فروردین, 1404

   If this is negatively affecting sleep period or high quality for a sustained time period,
   users should take Anadrol earlier in the day, or the dose ought to be lowered.
   This is the optimal protocol rather than taking drugs such as diazepam,
   as they put additional strain on the liver (28).
   Even natural sedative supplements, such as valerian root, are capable
   of having an adverse effect on liver values. We have found
   that anabolic steroids, including Anadrol, could cause insomnia in some customers as a result of extreme CNS stimulation. If you are a bodybuilder competing in a
   pure present they usually conduct random testing, they will be testing for Anadrol,
   among other anabolic steroids.
   This is as a result of the kidneys, and not the liver, are primarily responsible for metabolizing Anavar.
   However, we discover this to be a smaller proportion in comparison with
   other C17-aa steroids. Nonetheless, it may be very important note, individuals should adhere to the beneficial dosage and
   use the complement responsibly to anticipate these kinds
   of transformations.
   In this submit, we’ll look at essentially the most critical Anavar unwanted effects as
   well as the choice options obtainable to you. The degree of testicular atrophy can range from
   individual to individual and is usually dose-dependent.

   Some users could expertise solely gentle shrinkage, while others could notice
   more significant changes. It’s essential to notice that testicular atrophy is
   typically reversible once Anavar use is discontinued and natural hormone manufacturing resumes.
   However, the restoration process can take weeks or even months, and
   in some instances, medical intervention could additionally be
   needed to revive normal testicular operate. To safely cease using Anavar, it’s advisable to seek steering from a
   healthcare professional or a medical detox facility.

   As a half of the therapy for HIV/AIDS, the medication was used to stimulate
   the creation of latest muscle tissue in sufferers who suffer from situations that result in unintentional
   weight loss. Anavar, initially developed as a therapy for numerous medical circumstances, including muscle wasting
   diseases and osteoporosis, demonstrated efficacy in addressing certain cases of osteoporosis.
   Nevertheless, in 1989, Searle Laboratories decided to discontinue the manufacturing of Anavar.
   This choice was influenced, partly, by the adverse publicity stemming
   from situations of bodybuilders breaking the legislation and utilizing
   the drug illegally. When taken appropriately, Anavar can present
   a variety of advantages, primarily focused on muscle development, strength enhancement,
   and fats loss.
   Typical day by day dosages typically fall between 40mg-80mg, though specific requirements can range widely
   relying upon personal targets, physique composition, and tolerance.
   When it involves starting your complement regimen,
   it’s best to start with a softer dosage for a couple of weeks, before gradually growing if wanted.
   This gradual pathway allows your physique to adapt
   and signals any potential unwanted facet effects.

   Generally, a starting dosage of 20mg to 25mg per day is considered
   secure for the first few weeks. Anavar has a
   half-life of roughly 9 hours, which implies that it’s rapidly eradicated from the physique.

   To get the most out of your Anavar cycle and reduce any potential unwanted effects, there are a few dietary supplements and way of life changes you may want to think
   about. Anavar is processed by the liver, so it’s essential
   to help your liver well being during your cycle. Milk thistle and N-acetylcysteine (NAC) are
   two in style dietary supplements that can assist assist
   liver perform. When it comes to petering out Anavar, there are
   differing opinions in the bodybuilding neighborhood.
   Anavar is taken orally normally 2 to 4 times day
   by day or as directed by your doctor.
   Anavar can also be used to treat muscle-wasting ailments, osteoporosis, and different
   medical conditions that cause muscle loss. Anvarol is a authorized steroid different that’s designed to
   mimic the consequences of Anavar without the harmful unwanted facet effects.
   Anvarol is great for cutting cycles and may help you to attain a lean and toned physique.
   Another authorized steroid various that can be used instead
   of Anavar is Winstrol. Winstrol is a robust steroid that’s typically utilized by bodybuilders and athletes to
   extend strength and endurance. I am afraid there isn’t going to be much
   in this small chapter as Anavar just isn’t best for bulking in males, however it can be
   done. The cause it isn’t as a end result of it’s a comparatively weak steroid
   so large doses are want of upwards of mg every day and for sustained periods of eight
   or so weeks, which implies toxicity will build.
   But there isn’t a getting round the truth that Anavar remains to be a steroid.
   No steroid can truly be thought of a gentle substance when used at doses for bodybuilding; it’s just that Anavar
   is taken into account “pretty mild” compared to the actually heavy stuff.

   Anavar has many benefits, and it’s a compound that
   worked nicely for me up to now. It may or will not
   be right for you, and you’ll find out more about that in the guide beneath.
   It helps the physique use saved fat for power, which might lead to a discount in body fat, particularly when combined with a proper food plan and train regimen. This is why Anavar
   is often used during slicing cycles, where the aim
   is to lose fat whereas preserving muscle mass.
   This modification allows the compound to remain lively after ingestion,
   nevertheless it also means that the liver should work more durable to process the drug.
   This increased liver stress can result in elevated liver enzymes,
   a typical indicator of liver strain or injury.
   The two major enzymes which may be usually monitored are
   alanine aminotransferase (ALT) and aspartate aminotransferase (AST).
   Elevated levels of those enzymes can indicate that the liver
   is beneath stress and doubtlessly suffering injury. Anavar,
   also called Oxandrolone, has turn out to be a preferred alternative amongst bodybuilders
   and health lovers looking for to boost their physique
   and performance.
   I even have therefore put together two instance cycles to cowl each of those targets.
   Depending on results required and whether you’re male or female—the Anavar cycle dosage, and the opposite
   steroids it can be stacked with, varies. While most synthetics have some weight loss properties, in that they enhance
   the metabolism, Anavar really boosts lipolysis (fat breakdown).
   It’s thought that this is as a outcome of of its capability to simply bind to
   androgen receptors and inhibit thyroid-binding globulin. Additionally,
   this modification means Anavar has low androgenic properties, decreasing the
   possibility of unwanted effects in guys and making it one of the best steroids for ladies.
   In this text, I truly have put together every little thing you have to learn about this steroid.

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2. 

   نمره 5 از 5

   Flossie – 31 فروردین, 1404

   If you’re contemplating taking Anavar, you could be wondering how it impacts your libido.
   Anavar is a synthetic anabolic steroid that’s usually utilized by bodybuilders
   to increase muscle mass and power. Anavar
   is mostly favored by athletes and bodybuilders as a result of it tends to
   have fewer unwanted aspect effects compared to other
   anabolic steroids.
   In most international locations, together with the US, possessing, buying, selling, or utilizing anabolic steroids without a doctor’s prescription just isn’t authorized.
   Check with your local laws to search out out the specifics, and you will discover some nations are fairly lenient
   or even permissive of steroid use. Whereas it’s not common for steroid
   users in the US to get caught out and prosecuted for using gear, simply remember that the possibility is always there.
   You could be conversant in men who will do anything to keep away from the development of gynecomastia when using
   steroids on account of excessive estrogen levels.
   Even a slight voice change signifies that your steroids are beginning
   to stimulate virilization. With androgen receptors existing within the
   larynx and vocal muscles of females as well, the exact mechanism applies if you’re
   taking extreme doses of male androgens. Enlargement of the
   clitoris as a end result of presence of extra androgen hormones is an alarming facet effect however not uncommon in females who use high doses of
   potent androgens. Females who choose to use Testosterone, Dianabol, or other
   potent androgenic steroids will virtually all the time be conscious of and even prepared to tolerate this
   side effect.
   We have had sufferers who previously used Anadrol undergo from peliosis hepatis, a vascular condition where blood-filled cavities randomly distribute inside the
   liver parenchyma. Hypertension and cardiac hypertrophy
   (enlargement of the heart) are common considerations for us when treating patients who’ve frequently cycled Anadrol.
   Women usually take 5–10 mg of Anavar with no points; however, 25 mg of Anadrol is (surprisingly) thought of an excessive dose for ladies, but actually,
   it’s safe for sustaining femininity.
   Again, this process is critical for muscle development and stopping muscle loss during cutting cycles.
   Anvarol may help ladies improve energy, construct lean muscle mass, and burn fat.
   The natural components in Anvarol embrace soy
   protein isolate, whey protein focus, BCAAs, and ATP, all
   of which work collectively to extend energy ranges and enhance athletic efficiency.
   Bodybuilders and athletes who’ve used both Anavar and Anadrol have shared their
   real-world experiences and results. Anavar customers report reasonable but consistent positive aspects in lean muscle
   mass, enhanced fats loss, and improved athletic performance, with relatively delicate unwanted facet effects.
   Anavar is commonly deemed as a more appropriate alternative for women, primarily due to
   its mild androgenic results.
   In addition to muscle and energy improvements, Anavar has been reported
   to extend bone density and assist in recovery. These
   factors contribute to its popularity among athletes in search of
   a competitive edge. In addition, this versatile steroid
   has shown promising leads to ladies and youngsters dealing with osteoporosis,
   as it aids in promoting bone density. Due to its gentle nature, Anavar has been a most popular
   selection for medical functions because it poses fewer dangers when compared to stronger
   steroids.
   You would possibly use a bunch of compounds on this cycle,
   but one will usually be the MAIN compound that takes on the primary
   anabolic function during the cycle. The half-life of
   a steroid gives you a method of understanding how long that
   steroid will stay active in your system at a stage where performance and physical advantages will be
   noticeable and achievable. Once you’ve injected,
   the ester begins to detach from the hormone, and the place it is a
   lengthy ester, it could take a week or two earlier than the effects of the steroid
   kick in. It also takes longer to exit your system when you stop injecting, and this impacts if you begin PCT.
   By enhancing the efficiency of how your body uses nutrients from
   meals (mostly carbs, proteins, and fats), every calorie you take
   in is used to its full potential.
   Anavar is an oral steroid that is imagined to be fairly delicate in phrases of
   unwanted side effects. Clenbuterol also can shield muscle tissue when you’re dieting;
   it’s anti-catabolic. Curiously enough, Clenbuterol is not going to ever trigger a loss in muscle
   mass. The unwanted effects of Clenbuterol are actually why
   it is used recreationally; it could possibly trigger a great increase in Metabolism,
   making it an excellent weight-loss drug. Clen will trigger a fantastic enhance in metabolism, leading you to
   burn extra fats. It does have a quantity of unwanted effects,
   nonetheless, corresponding to tremors, sweats,
   elevated heart fee, and anxiety. The one beauty of Clen is the truth that it
   is anticatabolic, meaning it cannot burn muscle.
   This is a sizeable quantity of fats loss, contemplating these men were sedentary
   and not in a calorie deficit. Anadrol stacked with one other
   steroid could go away a girl unscathed in regard to masculinization;
   nonetheless, we see testosterone suppression, liver strain, and blood
   pressure as doubtless points. Primobolan helped these patients shift from a cachectic state into an anabolic one.

   It also eliminated water retention as a result
   of Primobolan not aromatizing into estrogen (being a dihydrotestosterone-based steroid).

   Inexperienced customers will share their unfavorable Anavar experiences, but so usually, this revolves around
   the truth that a person didn’t use a testosterone
   base when on an Anavar cycle! One thing to learn about DHT is that it isn’t powerfully anabolic
   like testosterone is11. It is, however, far more androgenic, as its affinity for binding to the androgen receptor is double that of testosterone12.
   Despite this, Anavar has a very low androgenic score, and
   anabolic score three to 6 occasions more potent
   than testosterone. Thus even should you took the whole bottle,
   you’re nonetheless most unlikely to see any muscle growth from this.

   In many areas, these anabolic steroids are classified as managed substances, making their possession and
   use illegal and not using a legitimate medical prescription. No, it is usually not beneficial to
   stack Anadrol and Anavar together as a end result of
   potential for extreme liver strain and different side effects.
   The dangers outweigh the potential advantages, so choosing one or the opposite is safer than working a separate
   cycle. Its potent anabolic results and ability to spice up purple blood
   cell manufacturing and oxygen delivery make it a superior alternative for enhancing general energy and energy.
   It consists of Testosterone, Primobolan, Trenbolone, HGH, IGF-1
   DES, and Insulin. Though Anavar is taken into account a gentle
   steroid, taking too much could be dangerous. Overdosing on Anavar may cause liver toxicity
   and increased blood strain.

   References:

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3. 

   نمره 2 از 5

   Colby – 31 فروردین, 1404

   Further, as water weight is of no concern with this steroid every last pound of tissue gained might be that of 100% pure lean muscle mass.
   Additional, as Anavar dosages are so low for most women, whereas the hormone isnt low cost, as
   a end result of they need so little it proves to be far more
   efficient on a value to profit ratio. Anavar is known for its ability that can assist you burn fats while preserving muscle mass.

   It also can enhance your power and endurance, which could be useful during a chopping cycle.

   Nevertheless, Anavar also can cause unwanted effects similar to hair loss, pimples, and
   clitoral enlargement in females.
   Girls can sometimes expect to burn roughly 2-2.5lbs of fats per week, together with going to the gym and dieting.
   All anabolic steroids will skew cholesterol
   levels in the mistaken path, with LDL (low-density lipoprotein) rising and
   HDL (high-density lipoprotein) lowering. Thus, Anavar is likely one of
   the few anabolic steroids available that girls can take to construct muscle and burn fats with out forming a masculine appearance.

   Popular stacking options embody combining Anavar with testosterone or other slicing agents like Winstrol.
   However, it’s crucial to method steroid stacking with caution and seek the advice of
   with a knowledgeable professional to ensure secure and
   effective use. With a blend of excessive bustiness and
   perplexity, we’ll unravel the potential effects you might expertise during this early phase.
   From the primary indicators of muscle definition to elevated energy ranges, we’ll cowl the vary of possibilities and share insights to assist you set realistic
   expectations.
   With one hundred pc natural ingredients you’ll have
   the ability to belief and at a really inexpensive
   worth. It is favored during chopping cycles due to its
   ability to assist fats loss whereas sustaining lean muscle mass.
   When coupled with a calorie-restricted diet and cardiovascular train, it could assist achieve the
   specified slicing results. In wrapping up the subject on Oxandrolone, it becomes evident that this compound is a significant player in the panorama of fitness and bodybuilding.
   Its benefits span the domains of energy features, fats
   loss, and muscle preservation.
   Anavar has gained important curiosity, particularly amongst female bodybuilders and athletes looking to construct lean muscle while minimizing potential health risks.
   Anavar promotes lean muscle mass development in women, avoiding the bulbous look commonly acquired
   when taking other anabolic steroids. It operates by way of stimulated protein synthesis, supporting the buildup of the muscles whereas keeping one within the line of being more female.
   Really, this advantages women who don’t like gaining massive muscular tissues but wish
   to outline their muscles. As such, Anvarol increases phosphocreatine ranges
   in muscle tissue, translating into enhanced ATP synthesis (adenosine triphosphate).

   This means, it creates energy on your muscle
   workouts and, in turn, increases its energy. More energy throughout exercises translates to more vitality
   consumption, more opportunities for the lack of body fats, and
   a rise in lean muscle tissue.
   This is extra more doubtless to occur in individuals who already have high blood pressure or different cardiovascular
   points. When planning your Anavar cycle, it is essential to think about your goals and regulate your dosage and cycle size accordingly.
   If you are looking to bulk up, you may need a better dosage and
   longer cycle. On the opposite hand, in case you are trying to cut, a decrease dosage and shorter
   cycle may be extra appropriate. Anavar might help you perform higher
   throughout cardio workouts, which can help you burn extra calories and enhance your total fitness.
   You can purchase Var using a quantity of fee methods
   together with Moneygram, RIA, Zelle, crypto (Bitcoin), bank wire transfers, debit, and credit cards.

   An important note; 5-alpha reductase inhibitors are sometimes
   used to combat androgenic side effects brought on by the use of anabolic steroids.
   Nevertheless, this won’t have a powerful affect when using
   Anavar as the Oxandrolone hormone just isn’t affected by the 5-alpha
   reductase enzyme. Virilization signs embrace physique hair progress, a deepening of
   the vocal chords and clitoral enlargement. Fortunately the
   virilization ranking of Anavar is extremely low; most
   girls can supplement with out falling to such effects so long as they complement
   responsibly. There will all the time be the problem of
   particular person response to deal with, but the Oxandrolone
   hormone continues to characterize the most secure anabolic steroid for
   feminine use. If virilization symptoms do happen for
   any reason, you may be inspired to discontinue use immediately and they will fade away.
   Anavar (Oxandrolone) is an oral anabolic steroid
   primarily used for growing muscle mass and power.
   Females who discover an initial voice change after increasing the dose by simply 1mg
   or 2mg will sometimes decrease the dosage to remove the virilizing danger.
   Nonetheless, I’ve come across many women interested in using Winstrol as a substitute or running
   a Winny cycle and comparing it to previous experiences with Anavar.
   In that case, you’re not likely to see a lot of Winstrol’s hardening or different effects, and you’d be higher off running an extended slicing or fat-burning cycle before considering Winny.

   Winstrol is the preferred and well-known brand name for the androgen and anabolic steroid Stanozolol.

   It is a derivative of dihydrotestosterone (DHT), which makes
   Winstrol similar to testosterone. Importantly, Winstrol is taken into account to have
   a extra powerful anabolic to androgenic impact in contrast with
   testosterone. As we navigate the riveting landscape of bodybuilding, it’s clear that Anavar, also called Oxandrolone, could be a significant ally.

   One of essentially the most disgusting elements of using steroids is that
   most of them will require you to manage them via injections.

   It means that you must prick your self each time you should take a
   doze. But with Anavar, you can overlook about maintaining
   a stash of syringes and needles in your house since you won’t be
   needing them for the administration of this steroid.
   This is as a end result of it is in pill kind and you will administer it just as you usually take your pain medication – all you want is a glass of water
   to swallow it down your throat. The proven reality that it’s oral is likely certainly one of
   the different reasons which makes it appealing to many women who desire to make use
   of steroids. In conclusion, Anavar can be a useful tool within the bodybuilding journey for women, supplied it’s used
   responsibly and in moderation. Success in bodybuilding comes from consistency, patience,
   prudent decisions, and above all—respect on your personal body.

   This process is named a cycle, and it is meant to help minimize the danger
   of unwanted effects whereas maximizing the benefits of the steroid.
   If you’ve been on the earth of anabolic steroids for a while, then their well being dangers and side effects shouldn’t be anything new to you.
   Anavar is doubtless considered one of the few steroids that truly encourages the breaking down of physique fat—a fact supported by most of
   the positive Anavar reviews. Combined with its capacity to retain lean muscle, this makes it probably the greatest cutting
   steroids. Within only a few days, customers of
   Anavar have reported elevated endurance and faster recovery
   times. Publish cycle therapy (PCT) is really helpful after
   taking Anavar to assist restore your pure testosterone production and stop any adverse effects.

   Although the changes could be much less dramatic, the positive aspects
   can still be significant. Anavar has several helpful qualities which have made women lean in path of utilizing it.
   For one, it successfully will increase metabolic price, aiding
   in quicker calorie burning, which in flip leads to fats loss.

   Its no secret fats loss may be pretty cussed, and
   this steroid helps you break previous your plateau.

   This cycle is usually utilized by bodybuilders and athletes during a cutting section to help them achieve a lean, toned physique.
   For men, an elevated firmness in muscular tissues, lean mass development
   and a notable discount in body fats will likely be observed.

   Power gains achieved ought to have enabled a step-up
   in exercise depth, resulting in a extra ripped and chiseled look.
   The outcomes for women are somewhat parallel, albeit generally displaying even enhanced results.

   They will likely see more seen leanness, muscle definition,
   energy increments, and a major drop in physique fats.
   The outcomes might go so far as a redefined, athletic physique that exudes power
   and fitness.
   Mastering the right approach to Anavar cycles is essential and may considerably have an effect
   on the desired outcomes. It’s important to emphasize that while
   Anavar could be a powerful software for ladies looking
   for to reinforce their health and physique, it is not a
   magic answer. The finest results come when Anavar use is combined with a solid
   basis of proper nutrition, consistent training, and overall healthy lifestyle habits.
   Moreover, the decision to use Anavar or any performance-enhancing substance should not be taken frivolously.
   It requires cautious consideration of personal
   targets, health status, and threat tolerance.
   The time between cycles, often referred to as the “off” period, is essential for allowing the physique to completely recover and maintain its natural hormonal stability.

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4. 

   نمره 2 از 5

   Tristan – 31 فروردین, 1404

   One of the primary concerns for girls using Anavar is the
   potential for virilization. While Anavar is much less more likely to
   cause severe virilization compared to more androgenic steroids, the risk still exists, particularly at higher doses or with prolonged use.
   While Anavar is often touted as one of the mildest anabolic
   steroids for ladies, it’s essential to grasp that its use still carries potential side effects and dangers.
   Being conscious of those potential opposed results is important
   for any woman contemplating or currently using Anavar as part
   of her fitness or bodybuilding regimen.
   This is typical of DHT-derivative steroids, with it being a potent
   male hormone. Anavar’s capability to extend energy is believed to be
   connected to the uptake of ATP and fluid inside the muscle
   cells. Cutting steroids also have the power to
   extend muscle growth, even when consuming fewer energy.
   Steroids that burn fat and improve muscle definition are generally identified as
   chopping steroids. Lab and/or medical checks (such as purple blood cell counts,
   liver perform, blood cholesterol levels, PSA test) should be accomplished while you’re taking this medicine.
   It’s important to note that the specific
   dosages and period of the chosen PCT protocol may differ, depending on the individual’s unique circumstances.

   However, the risk of severe liver issues and the reality that Anavar is intended only for short-term
   use argues against its safety as a bodybuilding or performance-enhancing drug.
   Some widespread unwanted aspect effects embody liver toxicity, acne, hair loss, and elevated cholesterol levels.
   Ladies may also expertise virilization, which
   includes symptoms corresponding to deepening of the voice,
   facial hair growth, and enlargement of the clitoris. It’s necessary to seek the guidance of a medical skilled before starting an Anavar cycle to minimize these dangers.
   To sum up, Anavar could be a viable choice for women in search of lean muscle positive aspects and medical use for particular purposes.
   However, it’s crucial to strategy its utilization with caution, stick to appropriate dosages,
   and contemplate the potential unwanted side effects to ensure the benefits outweigh the dangers.

   These peer networks extend into on-line boards [57] and could additionally be partly because of the lack of appropriate harm reduction responses and frameworks
   out there for this group. For example, earlier analysis demonstrates that women looking for advice and the experiences of different girls
   concerning AAS use must navigate male contributions on web
   boards [58]. For girls who use AAS, our information indicate that a hurt reduction dynamic
   doesn’t exist presently. Females who select to make use of these
   medicine are more secretive, and this doubtless has hyperlinks to increased stigma as indicated by some
   participants. More research is required to know how these challenges are experienced and navigated by AAS-using women to inform gendered approaches to harm
   reduction. Future research ought to try and discover tips on how
   to combine peer-led approaches and hurt discount frameworks
   more effectively amongst ladies using AAS.

   Conventional conceptualisations of girls participating in sport point in path of a socially acceptable building of females having
   to subtly steadiness hegemonic femininity and athleticism [47].

   It is essential for women contemplating Oxandrolone utilization to be aware
   of the potential virilizing effects. Virilization refers to the improvement of masculine characteristics such as deepening of the voice,
   extreme hair growth, and clitoral enlargement.
   While the chance of virilization with Anavar is relatively low, it
   is essential to closely monitor for any signs of these
   effects. Anavar is taken into account one
   of many mildest oral steroids in terms of hepatotoxicity.
   Nonetheless, excessive or prolonged use of Anavar can nonetheless have adverse effects on liver health.
   It is crucial to adhere to beneficial dosage tips and monitor liver operate regularly when using Anavar
   or any other oral steroid.
   Physique fat is significantly reduced with arms, shoulders, and back
   getting noticeably muscular. This is because it doesn’t result in virilization when taken in the right dosage.
   Examine information suggests it could decrease HDL (good cholesterol) and increase LDL (bad cholesterol).

   In conclusion, identical to with any medication, the potential for unwanted side effects exists with Anavar,
   but they typically manifest when misused or abused. Due To This Fact, adhering to recommended guidelines, including correct dosage and
   cycle size, and prioritizing general health through a balanced
   lifestyle can considerably mitigate these dangers.

   When used responsibly and under professional steerage, Anavar can provide benefits with minimal opposed effects.
   Bear In Mind, information and caution are your allies
   on this journey, making certain a protected and rewarding experience with anabolic steroids.
   Both women and men naturally produce testosterone, however the ranges of
   this hormone are considerably decrease in girls compared to males.

   These embrace the event of masculine options corresponding to excessive body
   hair, a deepened voice, and an enlarged clitoris. Common blood work and
   well being check-ups are essential components of accountable Anavar use.
   These tests may help monitor changes in hormone ranges, liver
   perform, lipid profiles, and different necessary well being markers.
   Any important deviations from normal ranges must be taken significantly and should necessitate changes to the dosage or cycle size, or even discontinuation of use.
   Anavar, also referred to as Oxandrolone, is a prescription treatment and
   is authorized when prescribed by a healthcare skilled for medical purposes.
   It is often used to promote weight achieve in patients who’ve misplaced
   weight as a outcome of sure medical situations.
   For newbies in bodybuilding, Anavar could be a light and
   efficient place to begin. It helps kickstart their
   muscle development journey with a lower dosage and a shorter cycle, sometimes lasting for six to eight weeks.
   This preliminary experience acquaints novices with the results of the compound, and in addition permits them to regulate the cycle
   primarily based on their targets and individual reactions.

   Tailored for those craving for substantial
   muscle gain and elevated energy, it has gained recognition within the
   bodybuilding group. Relying on your bodybuilding stage, whether
   or not you’re starting, maintaining, or mastering, the usage and cycle of Anavar will differ.

   Whereas SARMs can offer some comparable advantages in terms of muscle acquire and fat loss, their long-term security profile is
   still not well established. Anavar, regardless
   of being a controlled substance, has an extended history of use and more extensive analysis behind
   it, offering a better understanding of its long-term effects and dangers.
   Some women stack Anavar with other anabolic steroids like Winstrol to maximise muscle progress
   and fat loss. To achieve muscle mass without bloating or
   taking an excessive quantity of of a single substance, picture enhancing medication can typically be stacked together to supply extra advantages.

   Anavar resembles different anabolic steroids by method of its medical and non-medical functions, and its availability in oral kind may be extra handy for some users.

   The initial dosage serves as a foundation to determine
   if and when to boost the consumption. Creating a calorie deficit is key to maximizing fats loss while preserving muscle.
   Nevertheless, it’s crucial to search out the right stability and keep away from extreme restrictions.
   Think About consulting with a healthcare supplier or nutritionist to assess your caloric wants based mostly in your objectives, physique composition, and activity degree.
   By rising red blood cell production and enhancing nutrient absorption, it ensures that muscle
   tissue obtain more oxygen and nourishment.
   This permits girls to engage in longer, more intense cardio classes or weight training,
   even at low doses. Women typically divide their daily dose into smaller quantities all through the
   day to maintain extra secure levels within the physique,
   as Anavar is quickly absorbed.

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5. 

   نمره 3 از 5

   Jillian – 31 فروردین, 1404

   Consequently, the individual could not be capable of finish their exercise because
   of extreme discomfort. This is because of water filling contained in the muscle cell and fluid being
   expelled outside the muscle cell. Consequently, as extracellular water is no longer obscuring superficial veins, they become more seen. Liver damage should not be discounted as a potential side impact of Anavar, particularly if excessive doses are
   administered for prolonged durations. Loopy Bulk’s formulas are supported by clinical research
   and are safe for men and women to make use of.
   Some research even means that Anavar may help enhance your cardiovascular endurance.
   This function might make it a favourite among athletes who do sports activities or
   activities that want plenty of stamina. Some of those trenbolone cycles are
   extremely harsh, and we’ve discovered them to be very
   damaging to the physique (at least within the brief term).

   Despite the fact that Anavar is an oral steroid, the kidneys also course of it, so it doesn’t put a lot
   pressure on the liver.
   Consequently, stacking it with oral steroids can pose cardiac issues.
   Nonetheless, testosterone suppression may be extreme post-cycle,
   which means it might take several months for natural testosterone ranges to manage.
   Our sufferers often implement post-cycle therapy following trenbolone
   use to revive the hypothalamic-pituitary-testicular (HPT) axis.
   Some novices may utilize an Anavar-only cycle, with it posing much less toxicity than different
   anabolic steroids. Nonetheless, Anavar still causes doubtlessly troublesome side effects (which are detailed in the unwanted effects section below).
   Anavar’s muscle features might be barely lower than Winstrol’s,
   with fats loss being roughly equal.
   For additional energy gains, mix with SARMs corresponding
   to Ostarine at 12.5mg per day for the primary 5 weeks, then increase it to 25mg a day for weeks
   6-8. Unlike men, girls don’t must do PCT, so there’s nothing else to do once the cycle ends.
   As I talked about, Anavar is certainly one of the few steroids women can confidently use.
   Cycles should be limited to 6 weeks, and the dosage must be 10mg day
   by day. Some ladies might want to go further and add another two weeks to the cycle whereas growing the dosage for these ultimate two weeks up to 20mg
   daily, however monitor for any potential unwanted
   aspect effects.
   Anavar is one such compound that is C17 Alpha Alkylated,
   however Var can be identified for being much less hepatotoxic than most different oral anabolic steroids, as demonstrated by numerous research.
   It can be highly beneficial that users complement with
   a confirmed liver help and well being complement, corresponding to TUDCA/UDCA whereas
   using oral anabolic steroids. Anavar is thought to negatively have an result on levels of cholesterol, growing LDL (bad cholesterol) and lowering HDL (good cholesterol) levels, which may result in cardiovascular points.
   It can even trigger liver toxicity and harm, especially when used in high doses
   or over prolonged periods.
   50 milligrams of prime of the range product, a good dose, easily elevated to 80 milligrams per day if desired.
   People carry varying ranges of response some may show
   symptoms no matter accountable use and should discontinue
   use instantly in order to protect their femininity.
   In order to acquire the optimistic results of anavar while minimizing the side effects most males will need a large dose as a result of
   its extremely mild nature to have the ability to obtain athletic enhancement.
   Wholesome males can keep away from these side-effects
   with correct preventative measures coupled with responsible
   supplementation. Anavar can suppress pure testosterone manufacturing
   but solely barely because it has a light effect on SHBG and LH and no
   effect on FSH.
   Like Anavar, Anvarol helps enhance your power levels and physical
   performance by stimulating phosphocreatine synthesis in your
   muscle tissue, allowing you to exercise longer and more durable.
   If your objective is to lose fat and improve your general fitness, you might want to include
   some cardio in your routine whereas on Anavar. Cardio might help you burn calories and enhance your cardiovascular health.

   This steroid boosts purple blood cell manufacturing, which
   ups oxygen supply to the muscular tissues. All Steroids will negatively impact your cardiovascular system
   by rising cholesterol and blood strain levels.
   Females love this one; really, Anavar is essentially the most suited steroid
   a female may take, and I’ve seen numerous numbers of girls get a modern look while utilizing it.
   The 2023 bodybuilding season was stuffed with tight competitions and putting moments that gave bodybuilding followers a lot to debate over the previous 12 months.
   Last year’s bodybuilding period was crammed with upset victories and history-making reigns,
   with new faces rising to make the competitors tough.

   A lengthy Anavar bodybuilding cycle extends the experience over a extra extended interval,
   typically lasting between 12 to 16 weeks. By committing to a lengthier cycle, you give your self
   extra alternatives to witness vital modifications in both your
   muscle mass and general physique. Moreover, as Anavar works
   systematically, it has the potential to make a very exceptional influence.

   In The End, the only option for cutting will rely on your particular person wants and targets.
   If you’re on the lookout for a milder anabolic steroid with fewer side effects, Anavar could also be a great possibility for you.
   Anavar and Anadrol are both anabolic steroids that can be utilized for slicing.
   Nonetheless, they have totally different properties, and
   they will not be suitable for everybody.
   Nonetheless, any anabolic steroid (including Anavar) can doubtlessly cause cancer if
   utilized in high doses or for lengthy intervals. This is because anabolic steroids can improve the level of hormones such as
   testosterone and estrogen in the body, and these hormones
   have been linked to an increased danger of most cancers.
   TRT, or Testosterone Substitute Therapy, is a treatment that is commonly used to deal with low
   testosterone ranges in males. Testosterone is a vital hormone that performs an important function in varied
   bodily capabilities, similar to muscle growth,
   bone density, libido, and temper regulation. As men age, their natural testosterone
   levels can decline, resulting in a selection of signs similar to fatigue,
   decreased sex drive, and loss of muscle mass.
   TRT is a remedy that can assist to restore regular testosterone levels in males,
   thereby enhancing their total health and well-being.

   References:

   Buy Anabolic steroids (Medknigki-V-novokuznetske.Ru)

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   They may find a way to prescribe a different medicine that doesn’t cause this aspect impact.
   In addition, Anavar helps to increase protein synthesis, which
   is the process that helps muscular tissues to grow bigger and stronger.
   Although no anabolic steroid is 100% protected, some are categorised
   as important medicines by leading health organizations.

   In The End, when considering purchasing Anavar, it’s essential to prioritize both the authorized and well being features of the decision. By adhering
   to legal guidelines and choosing trusted sources, you can ensure a safe and authorized purchase
   of Anavar for your health or efficiency targets. Anavar, also referred to as Oxandrolone, is classed as a controlled substance
   in the Usa underneath the Controlled Substances Act.

   It falls under the category of Schedule III medication, that are
   substances that have a moderate to low potential for physical and psychological dependence.
   This classification means that Anavar is legal to possess with a prescription but is unlawful to make
   use of with out one.
   Lean muscle gains will range substantially among girls, but over a 6-week cycle,
   some females can see glorious gains of up to 5-10lbs, even whereas losing some physique fats.

   Testosterone Enanthate is a long-lasting ester that can be used for a 12-week cycle alongside Anavar.
   Food Regimen and current body weight will determine
   how far your fat loss can go, however a 5lbs loss of fat over a cycle when you’re already lean will improve the
   physique. 20-30mg is a secure place to begin for first-time Anavar customers who are nervous about unwanted facet effects.
   While this may be a good dosage vary if it’s your first time
   utilizing Anavar, some guys won’t see a lot of response at this stage.
   As all the time, flexibility in adjusting your dose during the cycle is
   needed.
   Low testosterone can thus be skilled for a number of months unless PCT (post-cycle therapy)
   is administered to shorten this recovery interval. Secondly, testosterone doesn’t pass by way
   of the liver, thus failing to stimulate hepatic lipase, an enzyme that may skew cholesterol levels within the incorrect path.
   There are a couple of reasons why testosterone doesn’t negatively have an effect
   on blood strain significantly. Firstly, it converts to
   estrogen, with the feminine hormone having a positive effect
   on blood lipids. Testosterone is an FDA-approved injectable steroid used to deal with
   millions of males all round the world who are deficient in pure testosterone.

   Given the sensitive nature of this article’s topic, we’d wish to clarify that no steroid may
   be thought of 100% secure, especially when purchased on the black
   market for cosmetic functions. Misuse of prescribed drugs
   also raises questions on a soldier’s loyalty to
   the service, compliance with legal guidelines, and safety clearance.

   I advocate testosterone cruising for four months following this
   cycle, preserving in mind there’s no assure of T levels returning completely back to normal after using Tren. One Other Anavar stack for males is a
   pure chopping cycle and contains another cutting-specialist steroid in Winstrol.
   Winstrol is amongst the greatest slicing compounds
   out there, and when combined with Anavar, it proves to be
   a potent duo for ultimate shredding. Regardless of what you’re stacking Anavar with,
   the cycle size of this steroid should nonetheless be now not than eight weeks.
   Masteron is good for working for a whole cycle, while Anavar is
   best used as a finishing steroid within the last weeks.

   This system helps detect irregularities, similar to extreme prescribing or multiple purchases from different suppliers, which could indicate unlawful distribution. Steering via
   the authorized landscape of Anavar requires diligence and caution. You
   should understand its medical purposes, adjust to authorized requirements, and acknowledge potential risks.
   Unauthorized use or possession results in severe penalties, together with fines and imprisonment.
   Misuse poses significant well being threats, urging you to seek safer alternate
   options and professional assist. By adhering to authorized pointers,
   prioritizing health, and considering accountable options, you guarantee
   compliance and well-being.
   Frequent pairings embody protein dietary supplements, creatine, and branched-chain amino acids (BCAAs).
   These supplements support muscle development and restoration, complementing Anavar’s muscle-building properties.
   Nevertheless, it is necessary to be cautious when stacking supplements to avoid overloading
   your body. Consulting with a nutritionist or health
   skilled may help you create a balanced supplement regimen tailored
   to your particular wants and objectives. For the feminine efficiency enhancing
   athlete, regardless of the objective of use, 5-10mg per day is often the proper dose.

   Bear In Mind, the key to a successful health journey is making knowledgeable decisions that
   align together with your values and objectives.
   By taking a thoughtful method, you’ll find a way to make the
   most of your fitness endeavors and achieve the results you want.
   While Anavar is understood for its gentle unwanted effects, it is essential
   to remain vigilant.
   These may be a few of the most debilitating and physique-ruining unwanted aspect effects of steroid use and embody bloating or water
   retention and gynecomastia. You can count on good dry features without estrogenic unwanted side effects until you embrace different aromatizing
   steroids in your Anavar stack. Winstrol is more probably to trigger virilization effects in ladies,
   including voice hoarseness30, zits, modifications in menstrual durations, and growth of facial hair.
   Females would need to use very low doses of Winstrol to avoid these effects, in the 4mg
   to 10mg every day vary.
   There are a variety of controversies surrounding the
   utilization of Anavar, one of the contentious
   being its security. Anavar is an artificial androgen which is used in conjunction with other anabolic steroids to extend muscle mass.
   Nonetheless, some folks consider that it isn’t protected
   to make use of Anavar as a outcome of it has been linked to severe health
   risks. Anavar (oxandrolone) is an oral anabolic steroid created in 1962 to advertise lean muscle mass in these suffering from muscle-wasting conditions.
   The other major goal when formulating Anavar was to create a mild drug with
   few side effects so ladies and youngsters might safely take it.

   References:

   steroid freak (etextpad.Com)

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    Además, PhenQ contiene ingredientes clave que ayudan a prevenir la producción de nueva grasa, lo que significa que puedes evitar el aumento
    de peso en el futuro. Independientemente del esteroide anabólico que
    use, la PCT debería ser una necesidad. Y cuando se trata de Anavar,
    todo depende de si está haciendo un ciclo solo de Anavar o si está usando otros esteroides.
    Los esteroides también tienen impacto sobre la salud mental, ya que pueden provocar cambios
    en el estado de ánimo, irritabilidad y, en algunos casos, incluso llegar a producir una depresión.
    Consulta con un entrenador private o un nutricionista para
    obtener más información sobre cómo mejorar tu rendimiento y
    apariencia de manera saludable y segura. La mejor manera de comprobar los niveles hormonales es, por supuesto, hacer un análisis de sangre.

    En este mundo digital, la mayoría de las personas son conscientes de su aspecto físico.

    Algunos de ellos obtienen resultados impresionantes,
    y otros siguen funcionando. Si tú también estás luchando, te ayudaré
    a encontrar los mejores suplementos que te permitan obtener los resultados deseados más rápidamente.

    Los efectos de los esteroides para la masculinización del cuerpo, así como los del crecimiento
    del músculo, inician con la síntesis de proteínas.
    Las proteínas son bloques construidos con capas de células, tejidos
    y órganos (incluyendo los músculos) y su sintetización se
    estimula mediante el consumo de esteroides.
    Aunque se prescriben varios medicamentos para la ginecomastia, el Dr.
    Azouz generalmente no recomienda estos medicamentos, ya que la cirugía
    es el estándar de oro para tratar la ginecomastia. La ginecomastia puede afectar negativamente el bienestar psicosocial de una persona, independientemente de su estatus en el culturismo.
    El tejido mamario y los pezones hinchados pueden hacer que
    los hombres eviten actividades sin camiseta.

    Se refiere a la ampliación del tejido mamario en los hombres, distinta
    de la pseudoginecomastia relacionada con el aumento de peso.

    La ginecomastia provoca un tejido mamario resistente que no responde a la pérdida de peso ni
    al ejercicio. El tejido graso puede quedar atrapado entre el
    tejido mamario y es difícil de perder. Incluso si no fuiste un culturista profesional pero
    usaste esteroides anabólicos para mejorar tu físico en algún momento, podrías desarrollar la condición.
    El post ciclo debe ser igual de importante que tu ciclo, de
    este depende conservar tus ganancias musculares
    y evitar los famosos efectos secundarios de el uso de esteroides.
    Como tal, los esteroides ayudan a desarrollar masa muscular (lo que se
    conoce como efecto anabólico) así como características sexuales masculinas (efecto androgénico) tanto en hombres como en mujeres.

    Los científicos han intentado probar la asociación entre los esteroides
    anabólicos y la agresividad administrando dosis altas de esteroides
    o placebo durante días o semanas a voluntarios humanos y evaluando después los síntomas
    conductuales. Generalmente, cuando se comienza a utilizar esteroides anabolizantes ocurre aumento del deseo
    sexual, porque los niveles de testosterona aumentan. Los esteroides son lípidos (es decir, grasas) con una cierta estructura química.

    Toma una decisión informada y habla con un médico antes de
    considerar el uso de esteroides anabólicos. La testosterona se considera el esteroide anabólico
    más seguro para los hombres. Es una hormona que se produce de forma natural
    en el cuerpo y, por lo tanto, suele ser muy bien tolerada por el cuerpo.
    Vale la pena mencionar que los esteroides cambian permanentemente
    la fisiología de sus músculos al aumentar el número de núcleos celulares y células satélites.
    Un mayor número de núcleos celulares significa una gestión más
    eficaz de su volumen y, en consecuencia, una expansión más rápida.
    Tienen un efecto de “memoria muscular”, lo que significa que incluso unos pocos años después de
    dejar de usar el AAS, construirá sus músculos más
    rápido que si nunca hubiera usado el dopaje. Un ciclo que consiste
    sólo en esteroides orales causa muy rápidamente la supresión de la testosterona y problemas relacionados.

    Muchas personas se dicen a sí mismas que solo tomarán esteroides
    durante una temporada o un curso escolar. Lamentablemente, los esteroides pueden ser
    adictivos, lo que dificulta mucho dejarlos de consumir.

    Para los pacientes que tienen fimosis, una crema con esteroides o una
    pomada aplicada directamente al prepucio a menudo
    funciona bien. El médico, dependiendo de cada situacion, mostrará cómo aplicar la pomada sobre la piel firme.
    La pomada suaviza el prepucio cuando se usa diariamente durante
    un tiempo de aproximadamente 4 u 8 semanas.
    Aquellos en quienes la afección no mejora, pueden usar
    una crema de esteroides para intentar aflojar la piel tensa.

    Tras su paso por Vice, se ha dedicado a escribir y su trabajo
    ha aparecido en medios como El País, El Periódico de España, ABC o
    Yorokobu, entre otros. Juanjo es experto en cultura y way of life, con un foco especial en el impacto que internet y las
    redes sociales están teniendo en nuestra sociedad y en el
    mundo. Por eso mismo, sus temas suelen tener también mucho
    que ver con cine, collection, psicología, relaciones personales y sexualidad.
    Para matar a un ser humano, sería necesario inyectar más de
    3ml de aire a la vez. Por supuesto, debe tratar de deshacerse de todo el aire de la jeringa antes de la inyección –
    la pequeña burbuja no nos matará, pero inyectada en la vena puede causar molestias
    y leves alteraciones en el ritmo cardíaco.
    Evite los ciclos de esteroides regulares, que contienen AAS potentes como
    Winstrol, para darle al cuerpo tiempo suficiente para recuperarse; de lo contrario, la testosterona baja o la infertilidad pueden convertirse en una
    realidad a largo plazo. Anvarol es el más adecuado para hombres o
    mujeres que desean reducir su porcentaje de grasa corporal,
    al tiempo que aumentan el tono muscular y construyen músculo magro.
    Por lo tanto, cuando la testosterona exógena se convierte en estrógeno, el líquido puede
    acumularse; causando hinchazón y músculos hinchados.

    También tiene el potencial de causar ginecomastia y, por lo tanto, el estrógeno puede necesitar controlarse para evitar la formación de tejido mamario
    femenino en la región pectoral. Esto se debe a que su cuerpo no ha tenido la oportunidad de acumular
    tolerancia a los esteroides anabólicos, lo que resulta en cambios rápidos y dramáticos en la composición corporal.

    Sin embargo, hay que tener en cuenta que la supresión de testosterona será más fuerte y la presión arterial subirá
    significativamente. Esto se debe a que son compuestos liposolubles, lo que significa que el esteroide se disuelve cuando se toma con la grasa de la dieta.
    El precio del Anavar en el mercado negro suele ser significativamente más bajo debido a que prácticamente todo es de grado UGL
    (laboratorios clandestinos), lo que cut back considerablemente los costos de producción. Por lo tanto, un hombre que tome
    20 mg al día durante 6 semanas con receta gastaría aproximadamente 820 €.
    Hoy en día, el precio de Anavar sigue siendo
    excepcionalmente alto para los pacientes que lo compran con receta médica.

    También es un esteroide oral, por lo que es un compuesto preferible para aquellos que
    buscan evitar las agujas. Anavar (oxandrolona) se clasifica como un esteroide
    de corte en la comunidad de culturismo, que a menudo se utiliza en la preparación de
    la competencia. La retención de agua también es probable,
    debido a que la testosterona tiene la enzima aromatasa presente.
    Para obtener más información sobre cómo darte de baja, nuestras prácticas de privacidad y cómo nos comprometemos a proteger y respetar tu
    privacidad, consulta nuestra Política de privacidad.
    Sin embargo, estos son esteroides muy caros y a menudo falsificados; por lo tanto, la testosterona inyectable es
    la opción preferida para muchos de nuestros pacientes.

    References:

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    Se basa en el consumo estratégico de esteroides anabólicos, de manera que el deportista consiga obtener el
    máximo rendimiento, pero disminuyendo los efectos secundarios y el
    coste económico de todos los anabolizantes a usar.

    Es por ello que estas sustancias también son conocidas como esteroides anabólicos androgénicos (EAA).
    Aunque los EAA se utilizan a menudo para aumentar la masa muscular, su
    consumo también puede tener efectos negativos en los músculos.
    El aumento prematuro de la estructura muscular puede dar
    lugar a desequilibrios musculares y aumentar el riesgo
    de lesiones tendinosas. En casos graves, la ruptura del tendón del bíceps también ha sido reportada en usuarios de EAA.
    De otra parte, la psiquiatra aclaró si los esteroides anabólicos androgénicos pueden o no provocar adicción entre las personas.

    Además, los andrógenos, pero no los estrógenos,
    aumentan los receptores beta adrenérgicos mientras disminuyen los receptores alfa adrenérgicos.
    Así como la activación de la espermatogénesis y la fertilidad y los cambios conductuales masculinos,
    como la ginefilía y el aumento del deseo sexual. Una población menor de células no epiteliales aparece entre los túbulos en la semana
    8 del desarrollo fetal humano. Durante el desarrollo de los mamíferos,
    las gónadas son capaces al principio de convertirse en ovarios o testículos.
    La dehidroepiandrosterona es una hormona esteroide producida en la
    corteza suprarrenal por el colesterol.
    Este complejo migra después al núcleo celular, donde se combina con una proteína
    nuclear e induce el proceso de transcripción de ADN a
    ARN. En 30 minutos se activa la polimerasa de ARN y la concentración de ARN comienza a aumentar
    en las células prostáticas; a continuación, se produce un aumento
    progresivo de la proteína celular. Tras varios días, la cantidad de ADN
    de la próstata también se ha incrementado y se ha producido un ascenso
    simultáneo del número de células prostáticas, lo que
    se conoce como hiperplasia (5,7,9,). Por tanto, la testosterona
    estimula la producción de proteínas en casi cualquier lugar del organismo, aunque aumenta de forma más específica las proteínas en órganos o tejidos “efectores” responsables del
    desarrollo de los caracteres sexuales masculinos, primarios y secundarios
    (5,7). Por otro lado, la ginecomastia es otro efecto adverso que en ocasiones ocurre en los
    deportistas que recurren a la administración de esteroides anabólicos androgénicos.
    La ginecomastia no es ni más ni menos que el aumento patológico del
    tamaño de las glándulas mamarias en el hombre. Los esteroides anabólicos
    fueron desarrollados a finales de la década de 1930 primordialmente para tratar al
    hipogonadismo, una condición en la que los testículos no producen suficiente testosterona para
    un crecimiento, desarrollo, y funcionamiento sexual normales.

    Sin embargo seria ridículo estar completamente
    en desacuerdo con estas observaciones debido a que se han realizado sobre sujetos altamente entrenados y en atletas motivados.
    Para mayor información sobre anabólicos esteroides,
    revisar artículos sobre farmacología del deporte y
    medicina deportiva de los países que conformaron la ex Unión Soviética.
    Los atletas pueden consumir esteroides por un período de tiempo, interrumpir el consumo y
    volver a empezar la toma de los fármacos varias veces durante un año (ciclos).
    Los períodos de descanso intermitentes se cree que son para permitir que
    los niveles endógenos de testosterona, el recuento de esperma y
    el eje hipotálamo-hipófisis-gonadal vuelvan a los valores normales.

    Típicamente, todos los esteroides muestran efectos androgénicos y
    anabólicos del mismo compuesto. La relación androgénica a anabólica es importante para determinar las aplicaciones
    clínicas de las sustancias que ejercen un efecto anabólico.
    Los compuestos que se utilizan en aplicaciones clínicas deben disminuir con el efecto androgénico cuando se proporciona tratamiento anabólico..

    Los esteroides anabólicos androgénicos (EAA) fueron desarrollados con fines
    terapéuticos para el tratamiento del hipogonadismo masculino, la pubertad
    tardía en varones y, posteriormente, se les encontró
    utilidad para el cáncer de mama, la osteoporosis y la anemia aplásica1.
    El uso ilícito de EAA sin prescripción médica, a dosis hiperbólicas y combinaciones múltiples,
    resulta cada vez más frecuente en un denominador común que incluye a hombres jóvenes,
    con un buen estado físico, deportistas aficionados o fisicoculturistas.

    Su consumo puede devenir en hepatotoxicidad, insuficiencia renal,
    hipogonadismo, hipertrofia miocárdica y depresión.
    Además, se ha observado un aumento en los dolores de cabeza
    y una mayor resistencia a la insulina en algunos
    usuarios. La intolerancia a la glucosa y las anomalías en el torrente sanguíneo
    también pueden ocurrir como resultado del consumo
    de EAA. En las mujeres, es común notar cambios en el ciclo menstrual, reducción en tejido mamario,
    crecimiento de vello corporal y facial, engrosamiento de
    la voz y calvicie de patrón masculino”. Pero, con los años su uso se ha hecho popular, de forma ilícita, entre jóvenes hombres y atletas como una forma para promover el aumento de masa muscular y rendimiento físico en escenarios deportivos. Ahora bien, estás ganancias de masa muscular y mejoras del rendimiento inducidas por los esteroides no están exentas de efectos secundarios. ➡️ En estudios posteriores, este mismo grupo de investigación trató de averiguar la relación dosis-respuesta de la testosterona en hombres jóvenes sanos, analizando los efectos de 25, 50, 125, 300 y 600 mg de enantato de testosterona a la semana sobre la composición corporal. El médico también debe ofrecer seguir la recuperación midiendo la concentración de testosterona en suero, inicialmente tres meses después de la interrupción del medicamento y, si el valor no normaliza, se continúa periódicamente (2,21,22).
    Estas hormonas son utilizadas por los médicos para contrarrestar las enfermedades que causan atrofia muscular, depresión y para mejorar la calidad de vida de las personas mayores de 40 años. Debido a su alta efectividad, también son populares entre los atletas – una encuesta realizada en el Reino Unido en 2017 muestra que hasta el 9,8% de los visitantes de los gimnasios declaran que usan esteroides anabólicos. Señales de testosterona no solo a través del AR nuclear, sino también a través de mAR, incluidos ZIP9 y GPRC6A. Se ha propuesto que la señalización diferencial a través de mAR puede estar involucrada en la disociación de los efectos anabólicos y androgénicos de AAS. De hecho, la DHT tiene menos del 1% de la afinidad de la testosterona por ZIP9, y la metribolona y la mibolerona AAS sintéticas son competidores ineficaces para el receptor de manera related. Estas mujeres tienen poca o ninguna producción de sebo, incidencia de acné o crecimiento de vello corporal (incluso en las áreas púbica y axilar).
    Está ocasionada por falta de una de las enzimas necesarias para la síntesis de cortisol, lo que provoca aumento de una hormona hipofisaria, ACTH, que estimula la producción de andrógenos suprarrenales. Se debe a una sensibilidad aumentada de la piel a los andrógenos, o al incremento de la actividad a nivel cutáneo, de una enzima llamada 5 alfa-reductasa, por propensión familiar a tener mayor número de folículos pilosos por unidad de área de piel. Se inicia con la pubertad y, en este caso, no provoca irregularidades en las menstruaciones, las hormonas circulantes y la fertilidad.
    El desarrollo de sistemas de información fiable, basados en evidencias científicas, la participación de profesionales y la extensión de los programas de análisis a los esteroides anabólico-androgénicos pueden ser algunas de las estrategias de reducción de riesgos que convendría aplicar con estas sustancias. Pues bien, en este artículo voy a tratar de explicaros qué son realmente los esteroides anabólicos, qué efectos pueden llegar a producir, qué riesgos tiene su consumo o por qué se emplean tanto en el culturismo. Los EAA que se han reducido en 5 alfa, como la DHT, y los andrógenos sintéticos en los que se ha modificado el anillo A no pueden aromatizarse, como es el caso de la trembolona, el primobolan, la oxandrolona, el masteron y el estanozolol y, por ende, no se pueden convertir en estrógenos y causar ginecomastia (2,6,7).
    La administración de dosis suprafisiológicas de EAA, además del hipogonadismo hipogonadotrópico secundario, puede generar un desequilibrio en el steadiness andrógenos/ estrógenos. El incremento, a causa de la aromatización, de la transformación periférica de los andrógenos en estrógenos induce un aumento de la síntesis de SHBG, marcador de hiperestrogenismo en el varón, con el consiguiente incremento de la ligazón de andrógenos a esta globulina. Si hay un marcado hiperestrogenismo, se puede administrar un antiestrógeno como el tamoxifeno, a dosis de mg/día. Si no se produce la regresión espontánea del hipogonadismo hipogonadotrópico, se deberá reactivar el eje hipófiso-testicular mediante la administración de gonadotropinas, con los inconvenientes mencionados previamente al referirnos al tratamiento de la esterilidad. En ocasiones, a pesar de la normalización de los parámetros bioquímicos y hormonales sanguíneos, persiste la disfunción sexual, por lo que se deberá considerar la etiología psicógena.
    Sólo un 2% de la testosterona se encuentra en forma libre en la sangre, el 53-55% está unida débilmente a la albúmina sérica y del 43-45% se encuentra fuertemente unida a la globulina enlazante de la testosterona-estradiol (TeBG) (2)(3). De una manera muy sintetizada se expondrá una introducción en la que se hablará de la testosterona, desde un plano fisiológico. Durante la noche es normal despertar para ir al baño, sin embargo, si esto ocurre más de dos veces, la persona podría tener nocturia, cuya causa podría ser urológica y estar relacionada con el consumo de algunos líquidos. El sangrado no siempre se produce, pero a veces sí, especialmente si se utilizan agujas de gran diámetro. Un enrojecimiento moderado y una sensación de calor pueden ser un síntoma de una ligera alergia al aceite en el que se disuelve la sustancia o a la cantidad de alcohol en la solución.

    References:

    injection for
    muscle growth

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